General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter HEK 293 BDKRB2 β-Arrestin Cell Line, 2 vials. (93-0189C1)
The PathHunter BDKRB2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. bradykinin) based activation of BDKRB2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged BDKRB2 and EA-tagged β-Arrestin-2. Activation of BDKRB2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Gentarget HEK293 / uGFP (unstable GFP) Stable Cell Line
This stable cell line is transformed from the adhesive enhanced HEK293 cells, stably expressing the unstable GFP (click to see sequence) fluorescent protein. It was established by transduction of the destabilized GFP expression lentivirus containing a Puromycin resistance marker. GFP is constitutively expressed at high-level under the enhanced CMV promoter (suCMV). The following expression construct was integrated into the cell line’s genome.
Eurofins Discoverx PathHunter U2OS TGFBR1/TGFBR2/ENG Dimerization Cell Line, 2 vials. (93-1122C3)
The PathHunter TGFBR1/TGFBR2/ENG Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. TGF-β1) induced dimerization of TGFBR1/TGFBR2/ENG receptors. This product uses EFC technology. The cell line included overexpresses TGFBR1 target protein fused to PK alongside TGFBR2 target protein fused to EA and untagged ENG. Upon ligand-induced dimerization of TGFBR1/TGFBR2/ENG, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter Jurkat IκB Degradation Cell Line, 2 vials. (93-1121C19)
The PathHunter Jurkat IκB Degradation Cell Line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting the NFκB pathway. This cell line enables detection of IκB levels, allowing for assessment of NFκB pathway activation-induced IκB degradation. This product uses EFC technology. The cell line included overexpresses IκB target protein fused to ProLabel. EA is contained in the detection reagent. Upon pathway-activation-induced degradation of IκB EFC signal is lost. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/pathways.
Eurofins Discoverx PathHunter U2OS MERTK Functional Cell Line, 2 vials. (93-1151C3)
The PathHunter U2OS MERTK Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated MERTK dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged MERTK and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter CHO-K1 GLP1R β-Arrestin-1 Cell Line, 2 vials. (93-0914C2)
The PathHunter GLP1R (ARR1) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. exendin-4) based activation of GLP1R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GLP1R and EA-tagged β-Arrestin-1. Activation of GLP1R stimulates the recruitment of β-Arrestin-1 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter DDR1 Functional Assay, 2 vials. (93-0894C3)
The PathHunter DDR1 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated DDR1 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged DDR1 and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
IPHASE PHARMA SERVICES LLC ICR/CD-1 Mouse PBMC,Frozen,5million
Peripheral Blood Mononuclear Cells (PBMCs) are a heterogeneous population of immune cells found in peripheral blood and isolated via density gradient centrifugation. They include lymphocytes—such as T cells, B cells, and natural killer (NK) cells—and monocytes.It can be applicated Immunological Research and Cell Therapy (CAR-T/CAR-NK). These products require shipment in LN2 container therefore customer need to return the container.
Cell Applications Inc Proliferating Coronary Artery Smooth Muscle Cells (HCASMC), Adult
Proliferating Coronary Artery Smooth Muscle Cells (HCASMC), Adult
Cell Applications Inc Cryopreserved Bronchial Epithelial Cells, COPD (HBEpC-COPD), Adult
Cryopreserved Bronchial Epithelial Cells, COPD (HBEpC-COPD), Adult
Cell Applications Inc Proliferating Bronchial Epithelial Cells (HBEpC), Adult
Proliferating Bronchial Epithelial Cells (HBEpC), Adult
Cell Applications Inc Proliferating Bronchial Epithelial Cells (HBEpC), Adult
Proliferating Bronchial Epithelial Cells (HBEpC), Adult
Cell Applications Inc Proliferating Skeletal Muscle Cells (HSkMC), Fetal
Proliferating Skeletal Muscle Cells (HSkMC), Fetal